Mediation analyses or the relationship between ELA, CMV seropositivity,
and the CD4/CD8 ratio, CD4+ CD57+ cells, and CD8+ CD57+ cells as outcomes with
standardized coefficients. (A) ELA considered as an independent variable,
CD4/CD8 ratio as the dependent variable, and CMV titer as mediator variable. (B)
ELA as independent variable, arcsine-transformed percentages of CD4+ CD57+ cells
as dependent variable, and CMV titer as mediator variable. (C) ELA as
independent variable, arcsine-transformed percentage of CD8+ CD57+ as dependent
variable, and CMV titer as mediator variable. Statistic modeling: ELA was
treated as continuous variable (age at adoption); values for control youth were
set to 0. In each path analysis, the dependent outcome controlled for sex and
age at blood draw. Significance was set at *p < 0.05, **p < 0.01,
***p < 0.001.