Skip to main content
. Author manuscript; available in PMC: 2020 Apr 18.
Published in final edited form as: Cell. 2019 Mar 28;177(3):654–668.e15. doi: 10.1016/j.cell.2019.02.010

Figure 4. Transcriptome analyses reveal a common signature of dentate Hopx+ neural progenitors across different developmental stages.

Figure 4.

(A) Venn diagram of the 5,000 most highly expressed genes in Hopx+ embryonic (E15.5; E), early postnatal (P4; P), and adult (P45; A) dentate progenitors identified 3,914 commonly expressed genes, which were then compared to the 5,000 most highly expressed genes of adult dentate gyrus samples (N) to determine 1,306 dentate progenitor-enriched genes. RNA-seq data for adult dentate gyrus is from (Su et al., 2017).

(B-C) Representative genome tracks showing the expression of two stem cell genes (B) and two neuronal genes (C) in dentate neural progenitors and adult dentate gyrus. Y-axis indicates normalized reads.

(D) Heat map illustrating the expression of stem cell genes and neuronal genes in dentate progenitors and adult dentate gyrus.

(E) Heat map illustrating the expression of dentate progenitor-enriched genes within select gene ontology (GO) terms in dentate progenitors and adult dentate gyrus.

(F) GO analysis of biological processes of the 1,306 dentate progenitor-enriched genes. Color indicates P values for GO term enrichment and circle size indicates the percentage of progenitor-enriched genes for each GO term.

See also Figure S4.