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. Author manuscript; available in PMC: 2019 May 2.
Published in final edited form as: J Med Chem. 2018 Jun 11;61(12):5187–5198. doi: 10.1021/acs.jmedchem.8b00042

Figure 3. Crystal structure (PDB entry: 3AL4) and M090-induced substitution of HA.

Figure 3.

HA structure from the swine-origin A (H1N1)-2009 influenza A virus A/California/04/2009.54 The RNA sequences of this strain are identical to those of A/California/07/2009 and A/Guangzhou/GIRD/07/2009 that we have used. (A) Amino-acid substitution found in HA. (B, C) Top and side view of the HA model. The M090-resistant site HA2-E74 is highlighted by spherical models in red and blue, respectively.