. Author manuscript; available in PMC: 2019 May 2.

Published in final edited form as: J Med Chem. 2018 Jun 11;61(12):5187–5198. doi: 10.1021/acs.jmedchem.8b00042

Table 2.

Effect against a broader panel of influenza A viruses.

Compound			M090	Amantadine	Oseltamivir
Antiviral activity (EC₅₀, μM)^a	H1N1	A/WSN/33	1.48 ± 0.22	>100	0.40 ± 0.08
		A/PR/8/34	2.23 ± 0.60	>100	0.13 ± 0.03
		A/PR/8/34 (NA-H274Y)	6.85 ± 1.85	>100	>10
	H3N2	A/HK/68	5.38 ± 0.32	1.00 ± 0.50	2.30 ± 0.90
	H3N2	A/Aichi/2/68	4.55 ± 0.80	ND^b	0.99 ± 0.05
	H7N3	A/duck/Guangd ong/1/1996	4.58 ± 0.66	ND	2.67 ± 0.56
	H9N2	A/duck/HK/ Y280/97	6.79 ± 0.44	ND	>10

The anti-influenza activity of M090 was evaluated by CPE assay and validated by PRA assay (Figure S1).

ND, not detected.