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. Author manuscript; available in PMC: 2019 May 2.
Published in final edited form as: J Med Chem. 2018 Jun 11;61(12):5187–5198. doi: 10.1021/acs.jmedchem.8b00042

Table 3.

Resistance Development under Pressure of M090a.

Passage no. EC50 (μM)b
0 0.30
1 0.34
2 0.32
3 1.70
4 8.70
5 13.8
6 25.6
7 >43.0
8 >43.0
9 >43.0

Resistance to M090 developed from passage 3 and became significant after passage 6.

a

The parent strain is A/Guangzhou/GIRD/07/2009.

b

EC50 values tested after each passage.