Table 4.
Pharmacokinetic parameters after a single intravenous administration of 0.1, 0.3, and 1 mg/kg of neurounina-1 to beagle dogs (n = 5).
| Parameter | Mean | SD | Min | Median | Max | CV% |
|---|---|---|---|---|---|---|
| Neurounina-1 (0.1 mg/kg) | ||||||
| AUC0-inf (ng∗h/mL) | 30.10 | 9.92 | 23.05 | 26.44 | 44.47 | 32.95 |
| AUC0-tlast (ng∗h/mL) | 26.10 | 9.85 | 18.37 | 23.00 | 40.01 | 37.74 |
| AUC%extrap (%) | 4.00 | 0.82 | 2.84 | 3.42 | 4.68 | 20.54 |
| C0 (ng/mL) | 32.47 | 7.24 | 24.90 | 30.64 | 41.50 | 22.30 |
| CL (L/h) | 46.24 | 11.30 | 31.93 | 47.69 | 59.17 | 24.44 |
| Ke (h-1) | 0.35 | 0.07 | 0.29 | 0.38 | 0.43 | 20.39 |
| t1/2 (h) | 2.02 | 0.40 | 1.60 | 1.67 | 2.38 | 20.10 |
| Vd (L) | 130.31 | 17.94 | 109.65 | 126.86 | 151.55 | 13.76 |
| Neurounina-1 (0.3 mg/kg) | ||||||
| AUC0-inf (ng∗h/mL) | 122.42 | 64.73 | 35.68 | 133.20 | 213.80 | 52.88 |
| AUC0-tlast (ng∗h/mL) | 115.81 | 65.88 | 28.53 | 127.76 | 208.96 | 56.88 |
| AUC%extrap (%) | 6.61 | 2.14 | 4.28 | 4.56 | 9.63 | 32.33 |
| C0 (ng/mL) | 110.54 | 90.32 | 44.80 | 100.43 | 260.00 | 81.71 |
| CL (L/h) | 47.57 | 41.36 | 19.92 | 35.47 | 120.24 | 86.95 |
| Ke (h-1) | 0.30 | 0.05 | 0.22 | 0.31 | 0.35 | 16.45 |
| t1/2 (h) | 2.36 | 0.44 | 1.95 | 2.16 | 3.10 | 18.91 |
| Vd (L) | 154.15 | 112.84 | 61.82 | 102.96 | 338.35 | 73.20 |
| Neurounina-1 (1 mg/kg) | ||||||
| AUC0-inf (ng∗h/mL) | 263.06 | 192.08 | 150.98 | 184.06 | 601.44 | 73.02 |
| AUC0-tlast (ng∗h/mL) | 257.28 | 190.91 | 147.67 | 179.65 | 593.62 | 74.20 |
| AUC%extrap (%) | 5.78 | 1.92 | 3.31 | 4.55 | 7.82 | 33.16 |
| C0 (ng/mL) | 222.90 | 170.33 | 34.70 | 196.62 | 490.00 | 76.42 |
| CL (L/h) | 69.15 | 31.93 | 17.12 | 74.91 | 94.05 | 46.17 |
| Ke (h-1) | 0.33 | 0.04 | 0.30 | 0.32 | 0.40 | 11.90 |
| t1/2 (h) | 2.13 | 0.23 | 1.75 | 1.94 | 2.30 | 10.66 |
| Vd (L) | 210.79 | 96.51 | 51.89 | 224.15 | 307.70 | 45.79 |
AUC, area under the plasma concentration vs. time curve; t1/2, elimination half-life; Ke, elimination rate constant; CL, clearance; Vd, volume of distribution.