Table 4. Multivariate Cox Hazard Proportional Analyses of Progression-Free Survival of All Patients (N = 76).
| Variable | GRIm-Score |
RMH score |
||
|---|---|---|---|---|
| HR (95% CI) | P | HR (95% CI) | P | |
| Age (years) | ||||
| < 70 | 1 (reference) | 1 (reference) | ||
| ≥ 70 | 0.60 (0.34 - 1.06) | 0.08 | 0.67 (0.38 - 1.19) | 0.17 |
| Histology | ||||
| Non-SQ | 1 (reference) | 1 (reference) | ||
| SQ | 0.92 (0.47 - 1.81) | 0.81 | 0.87 (0.45 - 1.69) | 0.68 |
| PD-L1 expression | ||||
| < 1% or NA | 1 (reference) | 1 (reference) | ||
| ≥ 1% | 0.57 (0.33 - 0.97) | 0.04* | 0.67 (0.39 - 1.16) | 0.15 |
| ECOG-PS | ||||
| 0 or 1 | 1 (reference) | 1 (reference) | ||
| ≥ 2 | 2.32 (1.28 - 4.20) | < 0.01** | 2.45 (1.35 - 4.41) | < 0.01** |
| No. of metastases | ||||
| < 3 | 1 (reference) | |||
| ≥ 3 | 1.92 (1.10 - 3.33) | 0.02* | ||
| GRIm-Score | ||||
| Low (0 - 1) | 1 (reference) | |||
| High (2 - 3) | 1.36 (0.75 - 2.44) | 0.31 | ||
| NLR | ||||
| < 6 | 1 (reference) | |||
| ≥ 6 | 0.90 (0.42 - 1.90) | 0.78 | ||
| RMH score | ||||
| Low (0 - 1) | 1 (reference) | |||
| High (2 - 3) | 1.76 (1.03 - 3.02) | 0.04* | ||
CI: confidence interval; ECOG-PS: Eastern Cooperative Oncology Group Performance Status; GRIm-Score: Gustave Roussy Immune Score; HR: hazard ratio; NA: not assessed; NLR: neutrophil-to-lymphocyte ratio; RMH score: Royal Marsden Hospital prognostic score; SQ: squamous cell carcinoma. *P < 0.05, **P < 0.01.