Table 4.
Comparing methods for identifying omalizumab responders | Most cost-effective alternative | Threshold |
---|---|---|
Likelihood that omalizumab candidate will be identified as an omalizumab responder via a trial of omalizumab therapy: 0.468 | FeNO measurement + omalizumab trial | No threshold |
Likelihood that omalizumab candidate will be identified as an omalizumab responder via a trial of omalizumab therapy: 0.633 | No threshold | |
Likelihood that omalizumab candidate will have FeNO >19.5 ppb: 0.434 | FeNO measurement + omalizumab trial | No threshold |
Likelihood that omalizumab candidate will have FeNO >19.5 ppb: 0.587 | No threshold | |
Likelihood that patient predicted to be an omalizumab responder (FeNO >19.5 ppb) will be confirmed as an omalizumab responder following a trial of therapy: 0.850 | FeNO measurement + omalizumab trial | No threshold |
Likelihood that patient predicted to be an omalizumab responder (FeNO >19.5 ppb) will be confirmed as an omalizumab responder following a trial of therapy: 1.000 | No threshold |
Abbreviation: FeNO, fractional exhaled nitric oxide.