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Significant increase in the expression of TN-C in the human pulmonary arterial smooth muscle cells on exposure to HIV-protein(s) and cocaine. Western blot (A) and densitometry analysis (B) of total lung extracts; and immunohistochemical staining of lung sections (C) from HIV-infected and /or IVDUs; TN-C mRNA (D) and protein expression (E-F) in the human primary PASMCs on treatment with cocaine and/or HIV-Tat.
