Figure 7:
Quantification of injured CEC densities as a function of percentage of applied pressure over peak applied pressure P/P0. Separated CECs within each annular region (Figure 5D) were counted and divided over the annular area to obtain the pressure-dependent density of injured cells. The mean sham injured/dead CEC density after indentation (Figure 6) is represented by the dotted line and the gray area denotes the range of injured/dead densities in the sham. A) Injured CEC densities for the 9 mN indentation force group. Injured/dead CEC densities below 98% of P0 were all significantly higher than the sham group (p < 0.05). B) Injured CEC densities for the 0.65 mN indentation force group (“contact only”). Injured/dead CEC densities below 78% of P0 fell within the range of injured/dead CEC density in the sham group. Mean values denoted by the solid red and blue lines.