Table 3a:
Profiles of differentially expressed genes in β2AR-KO transgenic AD model annotated to be related to MHC protein complex in Gene Ontology (Part I).
| Items | Gene ID | Fold Chg. | p Value | q Value |
|---|---|---|---|---|
| Histocompatibility 2, class II antigen A, beta 1 | 14961 | 8.871354 | 1.91E-06 | 0.000375 |
| CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) | 16149 | 6.436063 | 9.77E-06 | 0.001104 |
| cathepsin E | 13034 | 5.167045 | 2.08E-07 | 9.51E-05 |
| Histocompatibility 2, D region locus 1 | 14964 | 3.86412 | 6.03E-07 | 0.000192 |
| Histocompatibility 2, Q region locus 8 | 15019 | 3.623889 | 1.40E-05 | 0.001408 |
| Histocompatibility 2, K1, K region | 14972 | 3.259361 | 3.27E-05 | 0.002469 |
| Predicted gene 8909 | 667977 | 3.114538 | 8.43E-07 | 0.000229 |
| Proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2) | 16912 | 2.908455 | 3.20E-05 | 0.00244 |
| Histocompatibility 2, class II, locus Mb1 | 14999 | 2.430133 | 5.14E-07 | 0.000173 |
| Eukaryotic translation initiation factor 2-alpha kinase 2 | 19106 | 2.220892 | 4.71E-07 | 0.00016 |
| Histocompatibility 2, class II, locus Mb2 | 15000 | 2.132515 | 3.91E-08 | 2.70E-05 |
| Lymphocyte-activation gene 3 | 16768 | 2.047944 | 0.000108 | 0.005212 |
| Solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1 | 18173 | 2.006802 | 1.74E-05 | 0.001625 |
| Histocompatibility 2, O region alpha locus | 15001 | 1.993441 | 0.000614 | 0.01491 |
| Proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7) | 16913 | 1.861686 | 0.000539 | 0.013966 |
| Fc receptor, IgE, high affinity I, gamma polypeptide | 14127 | 1.769161 | 8.53E-05 | 0.004534 |
| Histocompatibility 2, K1, K region | 14972 | 1.763206 | 2.74E-06 | 0.000472 |
| DnaJ (Hsp40) homolog, subfamily C, member 16 | 214063 | 1.713747 | 1.49E-05 | 0.001453 |
| beta-2 microglobulin | 12010 | 1.684328 | 4.52E-05 | 0.003045 |
| Transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) | 21355 | 1.628326 | 0.003592 | 0.042868 |
| Fc receptor, IgG, low affinity Iib | 14130 | 1.62805 | 0.000151 | 0.006517 |
| Histocompatibility 2, M region locus 3 | 14991 | 1.626856 | 1.77E-05 | 0.001647 |
| Protein tyrosine phosphatase, non-receptor type 6 | 15170 | 1.62081 | 0.000859 | 0.018684 |
| Unc-93 homolog B1 (C. elegans) | 54445 | 1.538428 | 0.000216 | 0.00799 |
| Nucleotide-binding oligomerization domain containing 1 | 107607 | 1.503754 | 0.000728 | 0.016624 |