Table 4a:
Profiles of differentially expressed genes in β2AR-KO transgenic AD model annotated to be related to hydrolase activity in Gene Ontology (Top 30 increase).
| Items | Gene ID | Fold Chg. | p Value | q Value |
|---|---|---|---|---|
| Cathepsin C | 13032 | 5.514072 | 0.002342 | 0.033643 |
| Kallikrein related-peptidase 6 | 19144 | 5.377842 | 2.08E-07 | 9.51E-05 |
| Cathepsin E | 13034 | 5.167045 | 2.08E-07 | 9.51E-05 |
| Proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2) | 16912 | 2.908455 | 3.20E-05 | 0.00244 |
| Plasminogen activator, urokinase | 18792 | 2.825956 | 1.57E-09 | 2.64E-06 |
| Lysozyme 1 | 17110 | 2.51725 | 1.58E-06 | 0.000345 |
| Chymotrypsin-like elastase family, member 1 | 109901 | 2.386791 | 1.55E-08 | 1.38E-05 |
| Ectonucleotide pyrophosphatase/phosphodiesterase 6 | 320981 | 2.239908 | 1.35E-07 | 7.72E-05 |
| CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1 | 67655 | 2.216111 | 6.35E-06 | 0.000841 |
| Peptidyl arginine deiminase, type II | 18600 | 2.204623 | 9.15E-06 | 0.001061 |
| Heparanase | 15442 | 2.188486 | 6.48E-07 | 0.000198 |
| Dual specificity phosphatase 1 | 19252 | 2.12332 | 0.002496 | 0.034772 |
| Caspase 1 | 12362 | 2.095731 | 6.53E-05 | 0.00386 |
| Phosphatidic acid phosphatase type 2C | 50784 | 2.080684 | 1.81E-07 | 9.01E-05 |
| Ribonuclease, RNase A family 4 | 58809 | 2.073185 | 2.71E-07 | 0.000106 |
| Phospholipase D family, member 4 | 104759 | 2.053021 | 1.40E-06 | 0.000322 |
| Lysozyme 2 | 17105 | 2.031321 | 6.58E-06 | 0.000859 |
| Agmatine ureohydrolase (agmatinase) | 75986 | 2.030783 | 0.000198 | 0.007654 |
| ATP-binding cassette, sub-family B (MDR/TAP), member 1B | 18669 | 2.025545 | 3.16E-05 | 0.002415 |
| Cathepsin Z | 64138 | 2.001336 | 0.000111 | 0.0053 |
| Prolylcarboxypeptidase (angiotensinase C) | 72461 | 1.972664 | 5.00E-05 | 0.003226 |
| N-sulfoglucosamine sulfohydrolase (sulfamidase) | 27029 | 1.965037 | 1.81E-05 | 0.001656 |
| glucuronidase, beta | 110006 | 1.954243 | 1.93E-05 | 0.001715 |
| Suppression of tumorigenicity 14 (colon carcinoma) | 19143 | 1.915971 | 0.000214 | 0.007947 |
| Proprotein convertase subtilisin/kexin type 4 | 18551 | 1.914996 | 0.000861 | 0.0187 |
| 2',3'-cyclic nucleotide 3' phosphodiesterase | 12799 | 1.91379 | 8.14E-06 | 0.000968 |
| Proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7) | 16913 | 1.861686 | 0.000539 | 0.013966 |
| paraoxonase 3 | 269823 | 1.86039 | 1.43E-05 | 0.001416 |
| Phospholipase C, gamma 2 | 234779 | 1.819061 | 9.23E-06 | 0.001066 |
| Mannosidase 2, alpha B1 | 17159 | 1.755669 | 6.14E-05 | 0.003691 |