Table 4b:
Profiles of differentially expressed genes in β2AR-KO transgenic AD model annotated to be related to hydrolase activity in Gene Ontology (Top 30 decrease).
| Items | Gene ID | Fold Chg. | p Value | q Value |
|---|---|---|---|---|
| DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked | 26900 | −2.10674 | 0.002199 | 0.032358 |
| Phosphodiesterase 4A, cAMP specific | 18577 | −1.98027 | 7.42E-05 | 0.004177 |
| Protein tyrosine phosphatase, receptor type, O | 19277 | −1.97666 | 0.00269 | 0.035996 |
| Proteasome (prosome, macropain) subunit, beta type 5 | 19173 | −1.96916 | 1.71E-05 | 0.001616 |
| Glucosamine-6-phosphate deaminase 1 | 26384 | −1.95682 | 4.02E-05 | 0.0028 |
| N-acyl phosphatidylethanolamine phospholipase D | 242864 | −1.93054 | 0.000285 | 0.009404 |
| acyl-CoA thioesterase 1 | 26897 | −1.86093 | 0.000536 | 0.013913 |
| Spastin | 50850 | −1.75118 | 9.36E-06 | 0.001069 |
| DIS3 mitotic control homolog (S. cerevisiae) | 72662 | −1.74871 | 0.000286 | 0.009435 |
| Ectonucleoside triphosphate diphosphohydrolase 6 | 12497 | −1.74754 | 5.98E-05 | 0.003631 |
| Rhomboid, veinlet-like 3 (Drosophila) | 246104 | −1.7434 | 2.35E-05 | 0.001954 |
| Acyl-CoA thioesterase 7 | 70025 | −1.73511 | 4.17E-05 | 0.002877 |
| DEAD (Asp-Glu-Ala-Asp) box polypeptide 5 | 13207 | −1.70454 | 0.000419 | 0.011946 |
| Spastin | 50850 | −1.7034 | 0.001148 | 0.022269 |
| Protease, serine, 53 | 330657 | −1.69693 | 0.001317 | 0.024066 |
| Esterase D/formylglutathione hydrolase | 13885 | −1.6703 | 1.03E-05 | 0.001143 |
| Mannan-binding lectin serine peptidase 2 | 17175 | −1.65176 | 0.00124 | 0.023313 |
| Haloacid dehalogenase-like hydrolase domain containing 2 | 76987 | −1.64692 | 9.52E-05 | 0.004837 |
| Bisphosphate 3'-nucleotidase 1 | 23827 | −1.64313 | 0.000246 | 0.008591 |
| OTU domain, ubiquitin aldehyde binding 2 | 68149 | −1.63286 | 0.000229 | 0.008222 |
| Endo/exonuclease (5'-3'), endonuclease G-like | 208194 | −1.58646 | 0.001819 | 0.029331 |
| Histocompatibility 13 | 14950 | −1.57331 | 0.000107 | 0.005193 |
| Iduronate 2-sulfatase | 15931 | −1.573 | 0.00208 | 0.031336 |
| YME1-like 1 (S. cerevisiae) | 27377 | −1.57208 | 0.000551 | 0.014096 |
| Adenosine deaminase-like | 75894 | −1.57155 | 0.002845 | 0.037159 |
| Angiogenin, ribonuclease, RNase A family, 5 | 11727 | −1.5621 | 0.000464 | 0.012644 |
| Inositol polyphosphate-4-phosphatase, type II | 234515 | −1.54742 | 0.004207 | 0.046872 |
| Expressed sequence AI464131 | 329828 | −1.54346 | 0.000783 | 0.017454 |
| Myotubularin related protein 2 | 77116 | −1.5103 | 0.003353 | 0.041002 |
| Alkaline ceramidase 2 | 230379 | −1.50696 | 8.64E-05 | 0.004576 |