NO-dependent relaxation in small MAs. (A) Example of real-time recording of ACh-induced vasorelaxation in the absence and presence of L-NAME (0.1 mM). Black triangles mark the time of addition of ACh (10−9, 3×10−9, 10−8, 3×10−8, 10−7, 3×10−7, 10−6, 3×10−6, and 10−5 M). (B) Concentration-response curves of ACh in small MAs from the WKY-C, SHR-C, SHR-M, and SHR-H groups. (C) Summary of NO-dependent relaxation in the four groups. #P < 0.05 versus the SHR-C group; and $P < 0.05 versus the SHR-M group; n = 8 in each group.