Herpertz‐Dahlmann 2014.

Methods	Randomised non‐inferiority trial
Participants	Country: Germany Diagnostic tool: DSM‐ IV No. screened: 660 No. randomised: Total: 176 No. started trial: Total: 172; IP: 85; DP: 87 No. dropped out during intervention: Total: 29; IP: 10; DP: 19 No, dropped out during follow‐up: Total: 11; IP: 10; DP: 1 No. analysed (observed case): Differing N for various outcomes Mean age in years (SD): IP: 15·2 (1·5); DP: 15·3 (1·5) Age range in years: No detail Gender %: Female 100% Subtype purging %: No detail Subtype restricting %: No detail Age of onset: No detail Duration of illness (weeks): IP: 53·7 (39·6); DP: 42·4 (33·1) Baseline weight: No detail Baseline BMI: IP: 15·1 (1·2); DP: 14·9 (1·5) Baseline eating disorder scale score (MRAOS): IP 5·0 (1·7); DP: 5·6 (1·7) Baseline eating disorder scale score (EDI‐II Global Score): IP: 272·5 (59·4); DP: 248·8 (58·2) Baseline purging: No detail Comorbidity (Any): IP: 33 (44%); DP: 28 (38%), Affective, Anxiety, Obsessive Compulsive and Attention Deficit Hyperactivity Disorders Details on living arrangements: No detail Family education/employment/income: No detail Recruitment strategy: Multi‐site: 6 centres in Germany Exclusion criteria: Organic brain disease Psychotic or bipolar disorder Substance dependence or abuse Serious self‐injurious behaviour Insufficient knowledge of the German language IQ below 85
Interventions	Setting of care: Inpatient and outpatient Training/qualification of care provider(s): No detail Treatment manual: No detail Supervision of treatment: No detail Adherence to treatment: No detail Intervention group 1 Description: Inpatient therapy Admission to IP for medical observation or stabilisation during the first 3 weeks of the study. Multimodal multidisciplinary treatment programme based on weight restoration, nutritional counselling, CBT, and family therapy but undertaken in inpatient setting Length: Mean 14.6 weeks Intervention group 2 Description: Day patient therapy Admission to IP for medical observation or stabilisation during the first 3 weeks of the study. Multimodal multidisciplinary treatment programme based on weight restoration, nutritional counselling, CBT, and family therapy but undertaken in day‐patient setting Length: Mean 16.5 weeks
Outcomes	Eating psychopathology Morgan Russell Outcome Scales (MRAOS) Eating Disorders Inventory (EDI‐II) Global Score Behavioural indices BMI Number of eating disorder readmissions Costs, loss to follow‐up General Psychopathology and Obsessionality Brief Symptom Inventory
Notes	The differences between the IP and DP are unclear. It is not clearly stated how the treatments differed beyond the initial 3 week IP admission. Descriptions for discharge criteria and interventions appear to be the same. The family therapy component is not described.
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Computer‐generated randomisation sequence to randomly assign participants to continued IP or DP after 3 weeks of inpatient care
Allocation concealment (selection bias)	High risk	Patients and therapists could not be masked to treatment allocation
Blinding of participants and personnel (performance bias) All outcomes	High risk	Therapists and participants cannot be blinded in trials of family‐based therapy
Blinding of outcome assessment (detection bias) All outcomes	High risk	Assessors were initially masked but some participants inadvertently revealed their treatment allocation; masking was maintained for the primary outcome of BMI
Incomplete outcome data (attrition bias) All outcomes	Unclear risk	Differences in numbers at post‐intervention analysis and 12‐month follow‐up. Fewer participants included in post‐intervention analysis compared to follow‐up. Modified ITT analysis reported. There is an imbalance in the missing data across conditions (i.e. missing data from 10 participants in inpatient condition and only missing data from 1 in day patient condition).
Selective reporting (reporting bias)	Low risk	Outcomes appear to have been reported