Lock 2015.

Methods	RCT (unbalanced design)
Participants	Country: Not reported (author affiliation listed as USA) Diagnostic tool: DSM‐IV TR criteria for AN,except for the amenorrhoea requirement No. screened: 70 No. randomised: Total: 45; FBT: 10; FBT/IPC: 35 No. started trial: No detail No. dropped out during intervention: Total: 9; FBT: 2; FBT/IPC: 7 No. dropped out during follow‐up: No detail No. analysed (observed case): Unclear, no detail Mean age in years (SD): FBT: 14.3 (1.5); FBT/IPC: 14.6 (1.4) Age range in years: No detail Gender % female: FBT: 90; FBT/IPC: 92.07 Subtype purging %: No detail Subtype restricting %: No detail Age of onset: No detail Duration of illness, months: Total:12.6 (13.7) Baseline weight: No detail Baseline BMI : FBT: 16.1 (1.1); FBT/IPC: 16.2 (0.9) Baseline eating disorder scale score Global EDE: FBT: 1.8 (1.6); FBT/IPC: 1.9 (1.5) Baseline purging: No detail Comorbidity (depression, anxiety, obsessive compulsive, panic, phobia, adjustment disorders): FBT 30%; FBT/ICP: 52.4% Details on living arrangements, intact family: FBT: 80%; FBT/IPC: 85.3% Family education/employment/income: No detail Recruitment strategy: No detail Exclusion criteria: Psychotic illness/other mental illness requiring hospitalisation Were dependent on drugs or alcohol Physical illness that necessitated hospitalisation Physical conditions (e.g. diabetes mellitus, pregnancy) known to influence eating or weight Received previous FBT Not medically stable for outpatient treatment according to the recommended thresholds of the American Academy of Pediatrics and the Society of Adolescent Medicine
Interventions	Setting of care: Outpatient Training/qualification of care provider(s): No detail Treatment manual: Yes for FBT, unclear for FBT/IPC Supervision of treatment: No detail Adherence to treatment: No detail Intervention group 1 Description: Family‐based therapy (FBT) Includes a family meal Length: Sessions: Mean (SD) 12.9 (3.6); 6 months (target: 15 sessions over 6 months) Intervention group 2 Description: Family‐based therapy + intensive family coaching (FBT + IPC) In the adaptive treatment arm, FBT/IPC+ provides 3 sessions of IPC added to standard FBT focused on meal time coaching for families whose child had not gained 2.3 kg (4.8 lbs) by session 4. The first of these sessions (new session 5) is a family session designed to present the failure in sufficient weight gain by this point as a crisis and strives to reinvigorate the family to make definitive behavioural changes to support weight restoration. Following this session (new session 6), a session with the parents only is held to identify what impediments the parents perceive might be interfering with successful re‐feeding. Finally, a second family meal (new session 7) is held which includes direct coaching by the therapist to help address the specific challenges identified during the meeting with the parents alone. Following these 3 sessions, the treatment resumes the regular course of standard FBT. Participants in this arm who did gain 2.3 kg by session 4 did not receive the IPC sessions. Length: Sessions: Mean (SD) 13.9 (4.3); 6 months (target: 18 sessions over 6 months)
Outcomes	Eating psychopathology EDE Global Score Behavioural indices Recovery (% EBW > 95) Weight BMI General Psychopathology and Obsessionality CYBOCS YBCEDS Total BDI (RSE HRQ Global pathology and interpersonal functioning TSPE
Notes	Funded by: NIMH to Dr. Lock (PI) R34‐MH09349303, Dr. Le Grange (PI) R34‐MH093768, and Dr. Agras, (co‐PI), R34‐MH09349303
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	No detail
Allocation concealment (selection bias)	Unclear risk	No detail
Blinding of participants and personnel (performance bias) All outcomes	High risk	Therapists and participants cannot be blinded in trials of family‐based therapy
Blinding of outcome assessment (detection bias) All outcomes	Unclear risk	No detail
Incomplete outcome data (attrition bias) All outcomes	Unclear risk	Outcome data reported for all randomised participants (unclear if ITT or observed case outcome data used)
Selective reporting (reporting bias)	High risk	Parents Versus Anorexia Nervosa Scale, PvAn, not reported for all groups at end of treatment, Schedule for Affective Disorders and Schizophrenia for School‐Aged Children (6 ‐ 18 years) ‐ Present and Lifetime Version (K‐SADS‐PL) not reported at end of treatment. Family income data discussed but not reported
Other bias	Unclear risk	Unbalanced randomised design N = 10 in FBT; N = 35 in FBT/IPC (but N = 23 in FBT/IPC had only FBT, e.g. FBT/IPC‐; N = 12 in FBT/IPC had FBT and IPC, e.g. FBT/IPC+)