Table 1. Itemized comparison of selected publications that contain one or more formulae related to human gestation and pregnancy.
| Manuscript | [27] | [15] | [25] | [28] | [29] | [31] | [3] | [32] | [33] | Current |
|---|---|---|---|---|---|---|---|---|---|---|
| Presents original data* | N | N | N | N | N | N | N | N | N | N |
| Presents original compiled data* set(s) | Y | N | N | Y | N | N | Y | Y | Y | N |
| Presents original models† based on compiled data sets of Abduljalil et al. [28] | N | N | N | Y | Y | N | N | N | N | Y |
| Presents original models† based on compiled data sets of Abduljalil et al. [33] | N | N | N | N | N | N | N | N | Y | Y |
| (+) Employs and thoroughly describes rigorous statistical methods for parameter‡ estimation | Y | N | Y | N | N | N | Y | N | Y | Y |
| (+) Employs and thoroughly describes rigorous statistical methods for model† selection | N | N | N | N | N | N | Y | N | Y | Y |
| (+) Presents original models† for multiple maternal compartments | N | Y | N | Y | Y | Y | Y | N | N | Y |
| (+) Presents original models† for multiple fetal compartments | N | Y | Y | N | N | Y | N | Y | Y | Y |
| (+) Presents models that reflect a biologically accurate depiction of the fetal circulatory system§ | N | N | N | N | N | Y | N | N¶ | N | Y |
| (+) Presents explicit models† for “rest of body” compartments that yield feasible (e.g., non-negative) values for all relevant time points | N | N | N | N | N | N | N | Y | N | Y |
| (+) Systematically compares original models† with previously published models† | N | N | N | N | N | N | N | N | N | Y |
| (-) Presents models that contain errors or inconsistencies identified in the current manuscript | N | Y | N | N | Y | N | Y | Y | Y | N |
The labels “(+)” and “(-)” on the descriptions in the first column indicate features of models that are desirable or not desirable, respectively. Throughout the table, the symbols “Y” and “N” indicate a “yes” (positive) or “no” (negative) response, respectively, to the question implied by the corresponding entry in the first column.
*Refers to data describing compartment volumes, blood flow rates to compartments, glomerular filtration rates, and/or hematocrits in a human mother and/or fetus during pregnancy/gestation.
†Refers to models describing compartment volumes, blood flow rates to compartments, glomerular filtration rates, and/or hematocrits in a human mother and/or fetus during pregnancy/gestation. Note that here the term “models” does not refer to PBPK model(s).
‡Refers to parameters in time- or mass-dependent models for compartment volumes, blood flow rates to compartments, glomerular filtration rates, and/or hematocrits in a human mother and/or fetus during pregnancy/gestation.
§In this context, a “biologically accurate depiction of the fetal circulatory system” refers to one that explicitly acknowledges the existence of fetal blood vessels and routes (including the ductus arteriosus, ductus venosus, and foramen ovale) that do not occur in the adult circulatory system.
¶Zhang et al. [32] present a model for flow through the ductus venosus, but do not present models for flow through the ductus arteriosus or the foramen ovale.