Table 6.
Characteristics of Endomyocardial Biopsy in the Study Population
| Histological CS | Clinical CS Diagnosed by JCS 2016 Criteria | Clinical CS Diagnosed by JCS 2016, JMHW/JSSOG 2015, WASOG 2014 Criteria | DCM | Histological CS vs DCM (P Value) | Clinical CS JCS 2016 vs DCM (P Value) | Clinical CS JCS 2016, JMHW/JSSOG 2015, WASOG 2014 vs DCM (P Value) | |
|---|---|---|---|---|---|---|---|
| n=30 | n=32 | n=15 | n=53 | ||||
| Endomyocardial biopsy | |||||||
| Positive D2‐40 immunostaining, No. (%) | 27 (90) | 30 (94) | 13 (87) | 39 (74) | 0.075 | 0.021 | 0.29 |
| Lymphatic vessel count per mm2, median (IR) | 12.0 (4.0–40.0) | 4.0 (3.3–9.0) | 4.0 (4.0–7.0) | 2.6 (1.9–3.4) | <0.0001 | <0.0001 | 0.0015 |
| Granuloma with giant cell, No. (%) | 30 (100) | 0 | 0 | 0 | <0.0001 | n/a | n/a |
| Inflammatory cell infiltration, No. (%) | 30 (100) | 17 (53) | 8 (53) | 0 | <0.0001 | <0.0001 | <0.0001 |
| Mild (focal or diffuse) fibrosis, No. (%) | 2 (7) | 13 (41) | 4 (27) | 31 (58) | <0.0001 | 0.11 | 0.04 |
| Moderate mosaic fibrosis, No. (%) | 4 (13) | 6 (19) | 6 (40) | 13 (25) | 0.26 | 0.54 | 0.33 |
| Severe mosaic fibrosis, No. (%) | 21 (70) | 12 (38) | 4 (27) | 2 (4) | <0.0001 | <0.0001 | 0.02 |
| Fatty tissue located within fibroblasts, No. (%) | 5 (17) | 16 (50) | 7 (47) | 9 (17) | 1 | 0.0012 | 0.02 |
| Fatty tissue located in myocyte or isolated connective tissue, No. (%) | 5 (17) | 3 (9) | 1 (7) | 12 (23) | 0.58 | 0.15 | 0.16 |
Continuous variables are presented as median (interquartile range [IR]). CS indicates cardiac sarcoidosis; DCM, idiopathic dilated cardiomyopathy; JCS, Japanese Circulation Society; JMHW, Japanese Ministry of Health and Welfare; JSSOG, Japan Society of Sarcoidosis and Other Granuloma Disorders; WASOG, World Association of Sarcoidosis and Other Granuloma Diseases.