Table 3.

Multivariable Regression of the Association Between cfPWV With Structural Brain MRI Markers at ARIC‐NCS/Visit 5 (2011–2013, N=1255)

Quartiles of cfPWV	Log2 WMH Volume β (95% CI)	Presence of Cerebral Microbleeds Odds Ratio (95% CI)	Presence of Lacunar Infarcts Odds Ratio (95% CI)	Total Brain Volume (cm3) β (95% CI)	Alzheimer Disease Signature Volume (cm3) β (95% CI)
Quartile 1 (n=314)	Reference	Reference	Reference	Reference	Reference
Quartile 2 (n=314)	0.09 (−0.07 to 0.24)	1.24 (0.78 to 1.98)	0.88 (0.51 to 1.53)	−8.21 (−16.37 to −0.06)a	−0.59 (−1.35 to 0.17)
Quartile 3 (n=314)	0.09 (−0.07 to 0.24)	0.80 (0.49 to 1.31)	1.23 (0.71 to 2.12)	−13.92 (−22.46 to −5.39)	−0.44 (−1.18 to 0.29)
Quartile 4 (n=313)	0.24 (0.09 to 0.40)a	1.36 (0.85 to 2.17)	1.53 (0.87 to 2.70)	−18.30 (−27.54 to −9.07)a	−1.48 (−2.27 to −0.68)a
P value for trend	0.007	0.574	0.090	<0.001	0.002

Adjusted for age, sex, race‐center, education, apolipoprotein E ɛ4, heart rate, body mass index, ever smoker, diabetes mellitus, minutes of leisure‐time physical activity, mean arterial pressure, and intracranial volume (for WMH, total brain, and Alzheimer disease signature region volumes). Weighted for selection into undergoing MRI at ARIC‐NCS/visit 5. ARIC‐NCS indicates Atherosclerosis Risk in Communities–Neurocognitive Study; cfPWV, carotid‐femoral pulse wave velocity; MRI, magnetic resonance imaging; WMH, white matter hyperintensity.

^a P<0.05 vs reference.