Table 5.
Adjusted Mean Difference (95% CI) and 20‐Year Rate of Change in Standardized Domain‐Specific Cognition Factor Scores Across Quartiles of cfPWV, ARIC‐NCS/Visit 5 (2011–2013, N=3703)
| Quartile | General Cognitive Performance | Memory | Executive Function/Processing Speed | Language |
|---|---|---|---|---|
| Cross sectional: adjusted mean difference in factor score | ||||
| Quartile 1 (n=926) | Reference | Reference | Reference | Reference |
| Quartile 2 (n=927) | −0.02 (−0.07 to 0.04) | −0.02 (−0.10 to 0.07) | −0.005 (−0.03 to 0.02) | −0.03 (−0.09 to 0.04) |
| Quartile 3 (n=925) | −0.05 (−0.10 to 0.01) | −0.05 (−0.14 to 0.04) | −0.02 (−0.04 to 0.01) | −0.02 (−0.09 to 0.04) |
| Quartile 4 (n=925) | −0.09 (−0.15 to −0.03)a | −0.07 (−0.16 to 0.02) | −0.04 (−0.07 to −0.01)a | −0.06 (−0.13 to 0.01) |
| P value for trend | 0.002 | 0.110 | 0.013 | 0.123 |
| Longitudinal: adjusted difference in 20‐y rate of change in factor score | ||||
| Quartile 1 (n=926) | Reference | ··· | ··· | ··· |
| Quartile 2 (n=927) | −0.02 (−0.07 to 0.03) | ··· | ··· | ··· |
| Quartile 3 (n=925) | −0.08 (−0.13 to −0.03)a | ··· | ··· | ··· |
| Quartile 4 (n=925) | −0.17 (−0.22 to −0.12)a | ··· | ··· | ··· |
| P value for trend | <0.001 | ··· | ··· | ··· |
Estimates are β values (95% CIs). Adjusted for age, sex, race‐center, education, apolipoprotein E ɛ4, heart rate, body mass index, ever smoker, diabetes mellitus, minutes of leisure‐time physical activity, and mean arterial pressure. ARIC‐NCS indicates Atherosclerosis Risk in Communities–Neurocognitive Study; cfPWV, carotid‐femoral pulse wave velocity.
a
P<0.05 vs reference.