Table 4.
LSMD of ADIR and ADBR Between Patients Randomized to Receive Clopidogrel 75 mg vs Prasugrel 5 mg Once Daily for 12 Months
| Absolute LSMD (Clopidogrel–Prasugrel) | Lower 95% CI | Upper 95% CI | Adjusted P Value | |
|---|---|---|---|---|
| ADIR | ||||
| Acute | 0.182 | 0.034 | 0.329 | 0.8215 |
| Subacute | 0.088 | 0.069 | 0.106 | <0.0001 |
| Late | 0.016 | 0.014 | 0.017 | <0.0001 |
| ADBR | ||||
| Acute | −0.070 | −0.140 | 0.000 | 0.9195 |
| Subacute | −0.014 | −0.021 | −0.007 | 0.3524 |
| Late | −0.004 | −0.005 | −0.004 | <0.0001 |
Positive values indicate higher ADRs for clopidogrel 75 mg daily compared with prasugrel 5 mg daily; negative values indicate higher ADRs for prasugrel compared with clopidogrel; the higher the LSMD in absolute value, the greater the magnitude of effect. ADBR indicates average daily bleeding rate; ADIR, average daily ischemic rate; ADR, average daily rate; LSMD, least squares mean difference.
*LSMD and SE are calculated by fitting a generalized estimated equation model, with patients as repeated measure and assuming Poisson distribution. The Tukey honest significant difference method was used to adjust P values for post hoc multiple comparisons.