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. 2019 Jan 13;8(2):e008968. doi: 10.1161/JAHA.118.008968

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© 2019 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Estradiol decreases myocarditis but has no significant effect on sera soluble ST2 (sST2) levels in female mice with myocarditis. Female BALB/c mice received a sham operation and a control capsule without estradiol (E2) (Sham+Con), or an ovariectomy (Ovx) and a control capsule (Ovx+Con), or Ovx and E2 replacement (Ovx+E2). A, Representative histology of myocarditis at day 10 postinfection (magnification ×64). B, Representative photographs of uterine horns. C, Myocarditis assessed as the % inflammation in histology sections. D, Uterine horn weights. E, Sera sST2 levels were assessed using ELISA. C through E, Data show mean±SEM and are representative of 3 separate experiments (n=8–9/group) a is significantly different from b with P<0.05. P values determined using 1‐way ANOVA with Tukey's multiple comparisons test. ANOVA (C) myocarditis P=0.002, (D) uterine horn weight P<0.0001, (E) sST2 heart P=0.32, individual comparisons not significant.