Table 3.
Summary of univariate and multivariate Cox regression analyses of overall survival duration
| Parameters | Univariate analysis | Multivariate analysis | |||||
|---|---|---|---|---|---|---|---|
| HR | 95%CI | P | HR | 95%CI | P | ||
| 1 | Age | ||||||
| ≥55/<55 | 1.04 | 0.71–1.51 | 0.836 | ||||
| 2 | Gender | ||||||
| Male/female | 0.81 | 0.57–1.17 | 0.261 | ||||
| 3 | Histological type | ||||||
| Hepatocholangiocarcinoma/hepatocellular/fibrolamellar | 0.99 | 0.27–3.69 | 0.99 | ||||
| 4 | Histologic grade | ||||||
| G4/G3/G2/G1 | 1.05 | 0.84–1.3 | 0.671 | ||||
| 5 | Stage | ||||||
| IV/III/II/I | 1.38 | 1.15–1.66 | 0.001 | 0.82 | 0.66–1.03 | 0.088 | |
| 6 | T classification | ||||||
| T4/T3/T2/T1/NX | 1.67 | 1.39–2 | 0.00 | 1.87 | 1.48–2.35 | 0.00 | |
| 7 | N classification | ||||||
| N1/N0/NX | 0.72 | 0.5–1.04 | 0.083 | ||||
| 8 | M classification | ||||||
| M1/M0/MX | 0.73 | 0.5–1.06 | 0.097 | ||||
| 9 | Radiation therapy | ||||||
| Yes/no | 0.51 | 0.25–1.02 | 0.056 | ||||
| 10 | Residual tumor | ||||||
| Yes/no | 1.44 | 1.14–1.83 | 0.002 | 1.43 | 1.12–1.83 | 0.005 | |
| 11 | miR-454-3p | ||||||
| High/low | 1.72 | 1.18–2.51 | 0.005 | 1.58 | 1.06–2.34 | 0.024 | |