Table 2.
Controlled studies evaluating the efficacy of infliximab in the treatment of acute severe UC. Studies compared infliximab to placebo, prednisolone, or cyclosporine. Studies were retrieved by a systematic review of PubMed and the reference list of the selected papers.
| Reference | Control | Pts number (infiximab vs controls) | Infusions | Dose (mg/kg) | Follow-up | Surgery (%) | ||
|---|---|---|---|---|---|---|---|---|
| Infliximab | controls | p | ||||||
| Sands 200153 | Placebo | 11 (8 vs 3) |
1 | 5; 10; 20 | 2 weeks | 12.5 | 100 | <0.05 |
| 3 months | 50 | 100 | ||||||
| Ochsenkuhn 200454 | Prednisolone | 13 (6 vs 7) |
3 | 5 | 3 weeks | 0 | 0 | ns |
| Jarnerot 200552 Gustavsson 201055 |
Placebo | 45 (24 vs 21) |
1 | 4; 5 | 3 months | 29 | 67 | <0.05 |
| 3 years | 50 | 76 | ||||||
| Bossa 200956 | Cyclosporine | 21 (14 vs 7) |
3 | 5 | 1 month | 43 | 43 | ns |
| Laharie 201257 Laharie 201858 |
Cyclosporine | 115 (58 vs 57) |
3 ^ | 5 | 3 months | 21 | 17 | ns |
| 5 years | 35 | 39 * | ||||||
| Williams 201659 | Cyclosporine | 270 (135 vs 135) |
3 | 5 | 2 years | 41 | 48 | ns |
| Croft 201360 | Cyclosporine ** | 83 (38 vs 45) |
1 | 5 | 3 months | 24 | 47 | <0.05 |
| 1 year | 35 | 58 | ||||||
Notes: *Approximately 50% of the patients who avoided colectomy at 3 months with cyclosporine required switching to infliximab to maintain remission in the long-term follow-up. **Not randomized study. p: significance.
Abbreviation: Pts, patients.