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. 2019 Apr 4;12:2439–2449. doi: 10.2147/OTT.S196851

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© 2019 Wang et al.

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miR-216a is a direct target of differentiation antagonizing nonprotein coding RNA (DANCR) in glioma cells.

Notes: (A) miR-216a binding site in DANCR and mutated luciferase reporter construct containing DANCR. (B) Schematic diagram of the luciferase reporter construct containing DANCR. (C) Luciferase activities in glioma cells transfected with the psiCHECK-DANCR-wt and negative control (NC) mimics or miR-216a mimics, **P<0.01. (D) Luciferase activities in glioma cells transfected with the psiCHECK-DANCR-mutant and NC or miR-216a mimics. (E) miR-216a expression in normal human astrocytes (NHAs) and cells from glioma cell lines U-87 MG, U-118 MG, U-254 MG, and SHG-44, **P<0.01, ***P<0.001 vs NHA. (F) Silencing of DANCR increased miR-216a expression in glioma cells. ***P<0.001. (G) Suppression of DANCR reduced expression levels of LGR5, PI3K, and p-AKT in glioma cells.