Figure 5.

Serial transplantation of aged and young BM drives clonal collapse of reconstituted hematopoiesis. (A-B) Pie graphs show the distribution of Confetti colors in the nucleated cells of the PB, MPPs, and HSCs of each recipient. Each pie graph represents an independent mouse. Each column of pie charts refers to the same mouse. Vertical arrows indicate donor mice for the subsequent transplant. Results are shown at 4 and 16 weeks posttransplant. (A) Serial transplantation from young primary BM donors. (B) Serial transplantation from old primary BM donors. Data related to Figure 4A-C. Source data are provided in supplemental Table 1. Data for HSCs and MPPs at the quaternary stage are not shown as they were used for WES.