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. Author manuscript; available in PMC: 2019 Sep 1.
Published in final edited form as: Nat Neurosci. 2019 Jan 28;22(3):353–361. doi: 10.1038/s41593-018-0320-0

Figure 3.

Figure 3.

Consistency of effects in Independent studies. (A) iPSYCH XDX GWAS z-scores are associated with z-scores of the best proxy SNP in eADHD, eAFF, eANO, eASD, eBIP, eSCZ, eSR-MDD, and eXDX in aggregation (N=350 z-score pairs; linear regression: β = 0.10, s.e. = 0.02; t = 5.95; Supplementary Table 13), (B) iPSYCH XDX GWAS z-scores are associated with z-scores of the best proxy SNP in eSCZ only (N=50 z-score pairs; linear regression: β = 0.21, s.e. = 0.05; t = 4.16), and (C) iPSYCH XDX GWAS z-scores are associated with iPSYCH internal replication z-scores (N=50 z-score pairs; linear regression: β = 0.08, s.e. = 0.03; t = 3.01; Supplementary Table 14). Black lines show regression fit. Grey bars depict the mean and one standard deviation interval of replication effects for SNPs with positive or negative effects in the XDX GWAS. Bonferroni correction for 10 concordance tests, p < 0.005.