Table 1.

Genome-wide significant associations. Four loci indexed by genome-wide significant index SNPs in the XDX GWAS (n=46,008 cases, 19,526 controls) implicate a number of candidate genes. Standard errors are for logistic regression coefficients and on the natural log scale (ln(OR)). OR, Odds Ratio; SE, Standard Error; A1, Effect Allele; A2, Non-Effect Allele; Info, Imputation Information Score; Z, Regression coefficient test statistic; P, p-value.

Locus	Chr	Range (hg19)	Index SNP	Position	A1	A2	Info	OR	SE	P	Functional Candidate Genes
1	2q32.1	183,279,530-183,680,199	rs4322805	183,535,884	A	G	-	1.07	0.01	2.92 × 10−8	PDE1A, PPP1R1C
2	3p21.31-3p21.2	46,381,000-52,161,508	3:48644636:G:A	48,644,636	A	G	0.78	1.36	0.06	3.99 × 10−08	AMIGO3, AMT, APEH, ARIH2, ATRIP, BSN, C3orf84, CCDC36, CCDC51, CCDC71, CDHR4, CELSR3, COL7A1, DAG1, DALRD3, DHX30, FBXW12, GMPPB, GPX1, IMPDH2, IP6K1, IP6K2, KLHDC8B, LAMB2, MON1A, MST1, NCKIPSD, NDUFAF3, NICN1, P4HTM, PFKFB4, PLXNB1, PRKAR2A, QARS, QRICH1, RBM6, RHOA, RNF123, SHISA5, SLC25A20, SLC26A6, SMARCC1, SPINK8, TCTA, TEX264, TMA7, TREX1, UCN2, UQCRC1, USP19, USP4, WDR6, ZNF589
3	3q13.32	117,453,031-117,997,735	rs6780942	117,828,678	T	C	0.96	1.10	0.01	1.11 × 10−10	IGSF11
4	10q25.1	106,372,083-107,364,513	rs12265655	106,744,534	C	T	0.99	0.92	0.01	1.47 × 10−09	SORC3*

^*SORCS3 was implicated by overlap, not functional connection.