Table 2.
Independent Replication. The sign of the effect of studied allele from the logistic regression association test (Disc.; +, risk increasing; −, risk decreasing) from the discovery GWAS (46,008 cases, 19,526 controls) is presented against nine replications. The signs from logistic regression association tests in the iPSYCH replication cohort (Repl.; 4,481 cases, 2,682 controls) are concordant, although the effects are not significant (two-tailed p-values > 0.05). Looking up the effect of the four loci in the published association statistics of eight indepdnent studies (eADHD, n=2,960 cases, 4,519 controls; eAFF, n=9,240 cases, 9,519 controls; eANO, n=3,495 cases, 10,982 controls; eASD, n=7,387 cases, 8,567 controls; eBIP, n=9,784 cases, 30,471 controls; eSR-MDD, n=75,607 cases, 231,747 controls; eSCZ, n=34,241 cases, 45,604 controls; eXDX, n=33,332 cases, 27,888 controls) shows strong concordance in direction of effect, with some evidence of strict significance for replication. Full statistics in Supplementary Tables 9 (Disc.), 13 (eGWAS) and 14 (Repl.).
| Disc. | Repl. | eADHD | eAFF | eANO | eASD | eBIP | eSR-MDD | eSCZ | eXDX | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Locus | Sign | Sign | P | Sign | P | Sign | P | Sign | P | Sign | P | Sign | P | Sign | P | Sign | P | Sign | P |
| 1 | + | + | 0.26 | − | 0.81 | − | 0.63 | − | 0.96 | − | 0.56 | − | 0.58 | NA | NA | + | 0.14 | − | 0.52 |
| 2 | + | + | 0.14 | +* | 1×10−3 | + | 0.05 | + | 0.09 | + | 0.07 | + | 0.01 | NA | NA | +* | 9×10−4 | + | 3×10−3 |
| 3 | + | + | 0.3 | NA | NA | NA | NA | + | 0.35 | + | 0.28 | + | 0.26 | NA | NA | + | 0.18 | NA | NA |
| 4 | − | − | 0.16 | + | 0.92 | − | 0.05 | − | 0.06 | − | 0.3 | − | 0.43 | −* | 1×10−5 | −* | 8×10−5 | − | 0.02 |
Significant after Bonferroni correction for 36 tests accounting for four loci in each of nine replication GWAS). eXDX, external cross-diagnosis; eADHD, external attention-deficit, hyperactivity disorder; eAFF, external affective disorder; eANO, external anorexia; eASD, external autism-spectrum disorder; eBIP, external bipolar disorder; eSCZ, external schizophrenia. NA, comparable data not available.