Table 5.
Combined association of physical activity and body mass index with colorectal cancer risk in the Multiethnic Cohort, 1993–2013
| Moderate/vigorous activity (MET-hours/day) |
Body mass index | P for heterogeneity |
|||||
|---|---|---|---|---|---|---|---|
| ≥30 kg/m2 | 25‒<30 kg/m2 | <25 kg/m2 | |||||
| Cases | HR (95% CI)a | Cases | HR (95% CI)a | Cases | HR (95% CI)a | ||
| Men | |||||||
| <1.42 | 105 | 1.00 (ref) | 177 | 0.72 (0.57–0.92) | 141 | 0.73 (0.57–0.95) | |
| 1.42‒<2.86 | 71 | 0.88 (0.65–1.18) | 181 | 0.76 (0.59–0.96) | 127 | 0.66 (0.51–0.86) | |
| 2.86‒<4.86 | 69 | 0.71 (0.52–0.96) | 211 | 0.64 (0.51–0.81) | 174 | 0.64 (0.50–0.82) | |
| 4.86‒<9.14 | 76 | 0.77 (0.57–1.04) | 240 | 0.65 (0.51–0.81) | 203 | 0.64 (0.51–0.82) | |
| ≥9.14 | 73 | 0.72 (0.53–0.97) | 215 | 0.60 (0.48–0.76) | 162 | 0.51 (0.40–0.66) | |
| P for trend | 0.06 | 0.05 | 0.006 | 0.62 | |||
| Women | |||||||
| <1.42 | 121 | 1.00 (ref) | 94 | 0.60 (0.46–0.79) | 138 | 0.74 (0.58–0.95) | |
| 1.42‒<2.86 | 127 | 0.91 (0.71–1.16) | 157 | 0.76 (0.60–0.97) | 177 | 0.58 (0.46–0.74) | |
| 2.86‒<4.86 | 106 | 0.91 (0.70–1.19) | 126 | 0.63 (0.49–0.81) | 204 | 0.66 (0.52–0.83) | |
| 4.86‒<9.14 | 78 | 0.77 (0.58–1.02) | 137 | 0.72 (0.56–0.92) | 188 | 0.55 (0.43–0.70) | |
| ≥9.14 | 45 | 0.77 (0.54–1.08) | 87 | 0.73 (0.55–0.97) | 142 | 0.64 (0.50–0.82) | |
| P for trend | 0.06 | 0.44 | 0.86 | 0.19 | |||
Abbreviation: MET, metabolic equivalent.
a
Adjusted by Cox proportional hazards regression for age at cohort entry, race/ethnicity, family history of colorectal cancer, history of colorectal polyp, pack-years of cigarette smoking, multivitamin use, non-steroidal anti-inflammatory drug use, menopausal hormone therapy use for women only, and intake of alcohol, total energy, red meat, dietary fiber, calcium, folate, and vitamin D.