Table 6.
Combined association of physical activity and sitting time with colorectal cancer risk in the Multiethnic Cohort, 1993–2013
| Moderate/vigorous activity (MET-hours/day) |
Sitting time | P for heterogeneity |
|||||
|---|---|---|---|---|---|---|---|
| Cases | HR (95% CI)a | Cases | HR (95% CI)a | Cases | HR (95% CI) | ||
| Total sitting | |||||||
| ≥10 hours | >6‒<10 hours | ≤6 hours | |||||
| Men | |||||||
| <1.42 | 124 | 1.00 (ref) | 135 | 1.01 (0.79–1.29) | 164 | 0.89 (0.71–1.13) | |
| 1.42‒<2.86 | 116 | 0.97 (0.76–1.25) | 129 | 0.91 (0.71–1.17) | 134 | 0.88 (0.69–1.12) | |
| 2.86‒<4.86 | 135 | 0.80 (0.63–1.03) | 169 | 0.82 (0.65–1.04) | 150 | 0.81 (0.63–1.03) | |
| 4.86‒<9.14 | 154 | 0.82 (0.65–1.04) | 201 | 0.84 (0.67–1.06) | 164 | 0.81 (0.64–1.02) | |
| ≥9.14 | 88 | 0.67 (0.51–0.88) | 162 | 0.66 (0.52–0.84) | 200 | 0.82 (0.66–1.03) | |
| P for trend | 0.02 | <0.001 | 0.60 | 0.06 | |||
| Women | |||||||
| <1.42 | 94 | 1.00 (ref) | 106 | 1.21 (0.91–1.59) | 153 | 1.06 (0.81–1.37) | |
| 1.42‒<2.86 | 131 | 0.92 (0.71–1.20) | 159 | 1.08 (0.84–1.40) | 171 | 1.06 (0.82–1.37) | |
| 2.86‒<4.86 | 155 | 1.08 (0.83–1.39) | 146 | 0.98 (0.76–1.27) | 135 | 0.99 (0.76–1.29) | |
| 4.86‒<9.14 | 133 | 0.96 (0.74–1.25) | 153 | 0.95 (0.74–1.24) | 117 | 0.90 (0.68–1.18) | |
| ≥9.14 | 59 | 0.95 (0.69–1.32) | 108 | 1.02 (0.77–1.35) | 107 | 1.06 (0.80–1.40) | |
| P for trend | 0.64 | 0.70 | 0.70 | 0.89 | |||
| Sitting watching TV | |||||||
|---|---|---|---|---|---|---|---|
| ≥3 hours | 1‒<3 hours | <1 hour | |||||
| Men | |||||||
| <1.42 | 219 | 1.00 (ref) | 144 | 0.96 (0.78–1.19) | 50 | 0.82 (0.60–1.12) | |
| 1.42‒<2.86 | 191 | 0.90 (0.74–1.10) | 144 | 0.97 (0.79–1.20) | 40 | 0.91 (0.65–1.28) | |
| 2.86‒<4.86 | 223 | 0.81 (0.67–0.98) | 173 | 0.82 (0.67–1.00) | 52 | 0.88 (0.65–1.19) | |
| 4.86‒<9.14 | 269 | 0.85 (0.71–1.02) | 184 | 0.79 (0.65–0.96) | 59 | 0.93 (0.69–1.24) | |
| ≥9.14 | 200 | 0.68 (0.56–0.83) | 193 | 0.80 (0.66–0.97) | 51 | 0.71 (0.52–0.97) | |
| P for trend | <0.001 | 0.10 | 0.39 | 0.52 | |||
| Women | |||||||
| <1.42 | 171 | 1.00 (ref) | 133 | 1.02 (0.81–1.28) | 41 | 0.67 (0.48–0.94) | |
| 1.42‒<2.86 | 225 | 0.88 (0.72–1.07) | 165 | 0.85 (0.68–1.05) | 62 | 1.17 (0.87–1.57) | |
| 2.86‒<4.86 | 238 | 0.96 (0.79–1.17) | 143 | 0.79 (0.63–0.99) | 44 | 0.84 (0.60–1.17) | |
| 4.86‒<9.14 | 217 | 0.85 (0.70–1.04) | 128 | 0.73 (0.58–0.92) | 54 | 1.03 (0.76–1.40) | |
| ≥9.14 | 127 | 0.90 (0.72–1.14) | 118 | 0.97 (0.76–1.23) | 25 | 0.64 (0.42–0.98) | |
| P for trend | 0.57 | 0.71 | 0.24 | 0.52 | |||
Abbreviation: MET, metabolic equivalent.
a
Adjusted by Cox proportional hazards regression for age at cohort entry, race/ethnicity, family history of colorectal cancer, history of colorectal polyp, body mass index, pack-years of cigarette smoking, multivitamin use, non-steroidal anti-inflammatory drug use, menopausal hormone therapy use for women only, and intake of alcohol, total energy, red meat, dietary fiber, calcium, folate, and vitamin D.