Table 8.
Association between physical activity at 10-year follow-up and risk of subsequent colorectal cancer in the Multiethnic Cohort, 2003–2013
| Hours/day | Men (n=34,089) | Women (n = 41,921) | P for heterogeneityd |
||||||
|---|---|---|---|---|---|---|---|---|---|
| Cases | HR (95% CI)a | Casesb | HR (95% CI)c | Cases | HR (95% CI)a | Casesb | HR (95% CI)c | ||
| Recreational activity | |||||||||
| <0.21 | 158 | 1.00 (ref) | 135 | 1.00 (ref) | 171 | 1.00 (ref) | 154 | 1.00 (ref) | |
| 0.21‒<0.46 | 71 | 0.61 (0.46–0.80) | 57 | 0.59 (0.43–0.81) | 96 | 0.99 (0.77–1.28) | 84 | 1.05 (0.80–1.37) | |
| 0.46‒<0.82 | 98 | 0.75 (0.58–0.97) | 86 | 0.79 (0.60–1.05) | 80 | 0.95 (0.73–1.24) | 73 | 1.09 (0.82–1.45) | |
| 0.82‒<1.32 | 63 | 0.71 (0.53–0.96) | 58 | 0.81 (0.59–1.12) | 40 | 0.87 (0.62–1.24) | 35 | 0.97 (0.66–1.42) | |
| ≥1.32 | 63 | 0.62 (0.46–0.84) | 55 | 0.67 (0.48–0.92) | 34 | 0.95 (0.65–1.37) | 29 | 1.06 (0.70–1.60) | |
| P for trend | 0.01 | 0.09 | 0.55 | 0.88 | 0.38 | ||||
| Work-related activity | |||||||||
| <0.21 | 134 | 1.00 (ref) | 119 | 1.00 (ref) | 79 | 1.00 (ref) | 71 | 1.00 (ref) | |
| 0.21‒<0.46 | 119 | 0.85 (0.67–1.09) | 102 | 0.83 (0.64–1.09) | 144 | 1.16 (0.88–1.52) | 129 | 1.18 (0.88–1.57) | |
| 0.46‒<0.82 | 89 | 0.75 (0.57–0.98) | 74 | 0.71 (0.53–0.95) | 95 | 1.11 (0.83–1.50) | 83 | 1.13 (0.82–1.55) | |
| 0.82‒<1.43 | 55 | 0.71 (0.52–0.97) | 47 | 0.69 (0.49–0.97) | 50 | 0.98 (0.69–1.40) | 45 | 1.04 (0.71–1.51) | |
| ≥1.43 | 56 | 0.74 (0.54–1.02) | 49 | 0.71 (0.50–1.00) | 53 | 1.11 (0.78–1.58) | 47 | 1.16 (0.80–1.69) | |
| P for trend | 0.07 | 0.06 | 0.99 | 0.78 | 0.18 | ||||
| Moderate/vigorous activity (MET-hours) |
|||||||||
| <1.86 | 115 | 1.00 (ref) | 100 | 1.00 (ref) | 96 | 1.00 (ref) | 86 | 1.00 (ref) | |
| 1.86‒<3.34 | 74 | 0.67 (0.50–0.90) | 63 | 0.66 (0.48–0.90) | 105 | 0.94 (0.71–1.24) | 95 | 1.00 (0.74–1.34) | |
| 3.34‒<5.71 | 76 | 0.65 (0.49–0.88) | 62 | 0.61 (0.44–0.85) | 75 | 0.92 (0.68–1.25) | 64 | 0.96 (0.69–1.33) | |
| 5.71‒<10.3 | 98 | 0.66 (0.51–0.87) | 87 | 0.69 (0.51–0.92) | 79 | 0.90 (0.67–1.22) | 72 | 1.02 (0.74–1.41) | |
| ≥10.29 | 90 | 0.61 (0.46–0.81) | 79 | 0.62 (0.45–0.84) | 66 | 0.94 (0.68–1.30) | 58 | 1.05 (0.74–1.49) | |
| P for trend | 0.01 | 0.04 | 0.76 | 0.69 | 0.19 | ||||
Adjusted by Cox proportional hazards regression for age at 10-year follow-up and race/ethnicity.
Excluding participants with missing information on covariates at 10-year follow-up.
Further adjusted for family history of colorectal cancer, history of colorectal polyp, body mass index, pack-years of cigarette smoking, multivitamin use, non-steroidal anti-inflammatory drug use, menopausal hormone therapy use for women only, and intake of alcohol, total energy, red meat, dietary fiber, calcium, folate, and vitamin D.
Tests for heterogeneity between men and women were performed based on the multivariate-adjusted models.