. Author manuscript; available in PMC: 2020 May 1.

Published in final edited form as: J Intern Med. 2018 Dec 25;285(5):491–502. doi: 10.1111/joim.12844

Table 1.

Origins of macrophages in steady state and diseased tissue.

Organ	Macrophage source
Steady state myocardium	Mostly local proliferation, very little recruitment^10,14,16
Acute myocardial infarct	Exclusively recruitment from blood monocytes made in marrow and spleen^{8,16,49,63,75}
Chronically failing myocardium	Recruitment and local proliferation¹³
Steady state arterial wall	Local proliferation, cells derive from a pool of monocytes that were recruited shortly after birth¹²
Developing atherosclerotic plaque	Recruitment from blood, cells are produced in bone marrow and spleen³⁴
Mature atherosclerotic plaque	Local proliferation of cells that were recently recruited from blood³⁴
Steady state brain	Microglia depend exclusively on local proliferation; no recruitment¹¹
Acute stroke	Recruitment of neutrophils and monocytes; local proliferation and activation of microglia also contributes⁶⁷