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Shown is a theoretical illustration of tumor growth and evolution demonstrating how some of the different modes of tumor promotion and evolution in response to therapy may occur and evolve concurrently.
Abbreviations: CAF- Cancer associated Fibroblast, EMT – epithelial to mesenchymal transition, miRNA- micro-RNA, TAM – Tumor associated macrophage, TGF- β – transforming growth factor beta, TNF- α – tumor necrosis factor alpha
