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. 2019 Apr 22;285(5):479–490. doi: 10.1111/joim.12910

Figure 1.

Figure 1

The MUC2 mucin structure, intracellular packing and unfolding upon secretion. (a) Domain organization of the 5130 amino acids of the MUC2 mucin, N, N‐terminal; C, C‐terminal; D. von Willebrand D domain; B, von Willebrand B domain; PTS, proline, threonine, serine sequence that after glycosylation become a mucin domain; CK, cysteine knot domain. (b) MUC2 mucin drawn to scale and packed in the secretory granule. After secretion, bicarbonate helps to remove calcium from MUC2 by increasing the pH and binding calcium allowing the mucin polymer to unfold into a flat net‐like structure that organizes the inner colon mucus layer.