Figure 3.

rs61757955 is a highly prognostic germline variant identified in the TCGA dataset.

(A) Manhattan plot showing the p-values resulting from testing each germline variant by Cox regression, controlling for the 11 variables in bolded in Table 1.Two variants passed the FDR threshold in the TCGA dataset.

(B) A Kaplan-Meier plot depicting the deleterious outcome associated with rs61757955, adjusting for the eleven covariates.

(C) Receiver operator characteristic curve at 7 years. rs61757955 increases the area under the curve compared to the 11 covariates alone, suggesting that it improves the clinical model.

(D) Separation of patients on the basis of whether or not they have this germline variant to determine which genes are induced or repressed in patients with rs61757955. Subsequent gene set enrichment analysis reveals that patients with this germline variant exhibit upregulation of the genes involved with KRAS signaling.