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. Author manuscript; available in PMC: 2020 May 1.
Published in final edited form as: Cancer Discov. 2019 Feb 18;9(5):662–679. doi: 10.1158/2159-8290.CD-17-1444

Figure 4. The lateral groove of the BCL6 BTB domain mediates cell adaptation to repeated stress.

Figure 4.

. a, Shannon entropy values mapped onto the structure of BCL6 BTB domain. NCOR1 peptide shown in cyan. b, Fold change of cell death in murine B220+ splenocytes from Bcl6+/+, Bcl6RD2MUT, Bcl6BTBMUT or Bcl6+/+ treated with vehicle or RI-BPI that were heat shocked either once (tan) or serially heat shocked (red) (n=3–5 mice per group). c-f, Fold change of cell death in chicken DT40 B-cells (c), iguana IgH-2 epithelial cells (d), sea lamprey typhlosole cells (e) and drosophila S2 cells (f) treated with either vehicle (CON) or RI-BPI and heat shocked once (tan) or serially heat shocked (red) (n=3–6 biological replicates). P values were calculated by two-sided T-test. Data presented as mean ± s.e.m.