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. 2019 May 2;9:6831. doi: 10.1038/s41598-019-42992-3

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Diagnostic performance of plasma metabolites found to more accurately predict decreased kidney function in patients with a single kidney than creatinine. Metabolites are ranked by area under the receiver operating characteristic (AUROC) curve and p-value (A). The mean differences between control RV and control 1YR were compared to eGFR. Plasma levels of pyrocatechol sulfate (%CV = 9.0) (B), N,N,N-trimethyl-L-alanyl-L-proline betaine (TMAP, %CV = 6.2, C), bilirubin (%CV = 8.5, D), phenyl sulfate (%CV = 6.5, (E) and dimethyluric acid (%CV = 8.4, (F) are presented for control RV, control 1YR, living donor RV, living donor 1YR and transplant patients. Data is presented as mean ± SEM, *p < 0.05, **p < 0.01, FC = fold change.