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. 2019 May 2;9:6831. doi: 10.1038/s41598-019-42992-3

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Plasma metabolites most efficiently cleared by hemodialysis. Metabolites are ranked by area under the receiver operating characteristic (AUROC) curve and p-value (A). Pre and post-dialysis plasma levels of N,N,N-trimethyl-L-alanyl-L-proline betaine (TMAP, %CV = 6.2, B), o-sulfo-L-tyrosine (%CV = 8.1, C), N-methyl-2-pyridone-5-carboxamide (2-PY, %CV = 7.1, D), octanoyl carnitine (%CV = 12.0, E), creatinine (%CV = 9.0, F), uridine (%CV = 8.3, G), 1-methylhistidine (%CV = 12.9, H) and decenoyl carnitine (%CV = 6.1, I) are presented for control RV (n = 10), non-dialysis dependent CKD (NDD-CKD, n = 20), conventional hemodialysis (conventional HD, n = 10), nocturnal intermittent PD (NIPD, n = 10), frequent nocturnal HHD (n = 5), intermittent nocturnal HHD (n = 5), intermittent conventional HHD (n = 5), and short daily HHD (n = 6). Data is presented as mean ± SEM, and analyzed by repeated measures ANOVA with Sidak’s correction *p < 0.05, **p < 0.01, FC = fold change.