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. 2019 May 2;9:6843. doi: 10.1038/s41598-019-43139-0

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Exemplar raw data microarrays of human or mouse IgG seroreactivity. The microarrays were hybridized with human or mouse sera and developed for total IgG. T0 or naïve (N) represents pre-vaccination serum, T12 and T20 represent post-vaccination collection the 12 and 20 week time points respectively from the human high dose vaccinees while T6 represents terminal bleed from vaccinated mice after 2 doses. Spots representing highly immunogenic proteins in human or mouse sera are blocked in red. Duplicate spots are shown; the third replicate spot is not in close proximity to the first two spots.