Table 3.
Summary of individual vaccinee responses to antigens with high IgG reactivities.
| Protein name | Gene namea | Functionb | Individual vaccinee response to MenPF-1 OMV vaccinec | SBA?e | Variabilityf | |||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | P | A | ||||
| PorA | 0791 | Transport | <3 | 8 | 6 | 5 | 11 | 5 | 4 | 5 | 7 | 10 | 4 | 6 | <3 | 27 | 10 | 5 | 6 | 7 | <3 | 6 | 14 | 8 | 4 | 5 | 4 | YES76 | YES77 | YES78 |
| RmpM | 0378 | OM stability | 4 | 7 | 5 | <3 | 3 | 9 | <3 | 8 | 13 | 16 | 5 | 4 | 3 | 19 | 15 | 5 | <3 | 4 | 6 | 7 | 7 | 8 | 15 | <3 | 3 | YES56 | NO79 | NO80 |
| PorB | 1982 | Transport | 5 | 13 | 29 | 18 | 16 | 12 | — | — | 6 | — | 19 | 47 | 107 | 95 | — | 42 | 38 | 195 | 9 | — | 76 | 8 | 30 | 10 | <3 | YES81 | NO82 | YES83 |
| PilQ25–777 | 1758 | Type IV pilus formation | 0 | 27 | 8 | 7 | 13 | 14 | 4 | 15 | 14 | 93 | 5 | 9 | 18 | — | — | 7 | 29 | 21 | 12 | <3 | 5 | 3 | 14 | 13 | 3 | YES63 | NO79 | NO84 |
| OpcA (D) | 1117 | Adhesion | 4 | 5 | <3 | 5 | <3 | 3 | 3 | <3 | 3 | <3 | <3 | 4 | <3 | 7 | 3 | 9 | <3 | 5 | <3 | <3 | <3 | 3 | <3 | <3 | <3 | YES85 | YES86 | NO87 |
| OpcA (M) | 1117 | Adhesion | 6 | 6 | <3 | 3 | <3 | 5 | <3 | <3 | 4 | <3 | 4 | 3 | <3 | 9 | 4 | 6 | <3 | 3 | <3 | <3 | 4 | 3 | <3 | <3 | 3 | YES85 | YES86 | NO87 |
| BamC | 1243 | Protein assembly | — | — | 18 | <3 | 24 | — | — | 41 | 13 | 95 | <3 | <3 | 13 | 91 | 5 | — | — | 109 | 21 | 32 | — | — | 112 | 13 | 4 | YES43 | NO43 | NO43 |
| PilQ25–580 | 1758 | Type IV pilus formation | 3 | 5 | 4 | 3 | <3 | 3 | 3 | <3 | 11 | 10 | <3 | 4 | 5 | 43 | 3 | 4 | 6 | 5 | 3 | <3 | 4 | 3 | 4 | <3 | <3 | YES63 | NO79 | NO84 |
| GNA1162 (M) | 1046 | Unknown | 3 | 5 | <3 | <3 | <3 | <3 | <3 | <3 | <3 | <3 | <3 | 3 | <3 | 5 | <3 | <3 | <3 | <3 | 3 | <3 | 6 | 3 | 4 | <3 | <3 | — | — | — |
| GNA1162 (D) | 1046 | Unknown | <3 | <3 | <3 | <3 | <3 | 3 | <3 | <3 | <3 | <3 | <3 | 3 | <3 | 5 | <3 | <3 | <3 | <3 | <3 | <3 | 5 | 4 | <3 | <3 | <3 | — | — | — |
aProteins are listed as the last 4 digits of their NCBI protein accession number or gene numbers (NMBH4476_).
bProtein function is detailed based on previous experimental findings or predictions from the Pfam database75.
cValues represent the proportional increase in serum reactivity to antigen i.e. (fluorescence value at T20)/(fluorescence value at T0). Where the T0 value was very low or zero, the cell is left blank.
ePublished Serum Bactericidal Assay to a homolog.
fPhase (P) and antigenic (A) variability of antigens.
gM, monomer; D, dimer.