Fig. 4.

Amplification of ZPF36L2 and MYC super-enhancers. a Rearrangements localized in the MYC-coding and -enhancer regions. b Rearrangements localized in the ZPF36L2-coding and neighboring-noncoding regions. Chromatin interaction, measuring by Hi-C in the cell line IMR90, is presented in the vicinity of ZFP36L2 locus. The topologically associated domains (TAD) are shown as adjacent red and blue bars. c Validation of TD-induced amplification of ZFP36L2 super-enhancers in an HK WGS cohort (n = 100). d Comparison of ZFP36L2 expression between samples with or without focal amplification in the TCGA GC cohort. Center line represents the median of mRNA expression and P value was derived from Wilcoxon rank-sum test. TD tandem-duplication