Table 3.
Reported complete excision rates of benign, ADH, DCIS, and IDC lesions
| First author | Definition complete excision | Benign complete excision rate n/N (%) | ADH complete excision rate n/N (%) | DCIS complete excision rate n/N (%) | IDC complete excision rate n/N (%) | Total complete excision rate n/N (%) |
|---|---|---|---|---|---|---|
| Sie et al. (4) | No residual disease at surgical specimen | NA | 21/32 (65.6) | 1/115 (0.9) | NA | 22/147 (15) |
| Killebrew et al. (9) | BLES produced a diagnosis of DCIS or ADH and surgical biopsy resulted in a benign diagnosis with no evidence of IDC, DCIS, or ADH | NA | NA | 12/31 (38.7) | NA | 12/31 (38.7) |
| Allen et al. (5) | No residual disease at surgical specimen | 5/6 (83.3) | NA | 4/6 (66.7)a | 3/6 (50)b | 12/18 (66.7) |
| Seror et al. (10) | No residual disease at surgical specimen | 0/1 (0) | 2/9 (22.2)c | 11/27 (40.7) | 1/7 (14.3)d 0/2 (0)e |
14/46 (30.4) |
| Diepstraten et al. (11) | NA | NA | NA | 1/19 (5.3)f | NA | 1/19 (5.3) |
| Whitworth et al. (6) | NA | NA | NA | NA | NA | NA |
| Razek et al. (12) | 1 mm free margin after BLES | NA | 20/24 (83.3)g | 6/8 (75) | 3/6 (50) | 29/38 (76.3) |
| Medjhoul et al. (13) | No residual disease at surgical specimen | NA | 3/4 (75) | NA | 0/10 (0) | 3/14 (21.4) |
| Al-Harethee et al. (7) | NA | NA | NA | NA | NA | NA |
| Allen et al. (14) | No residual disease at surgical specimen | NA | 3/6 (50) | 6/11 (54.5) | 5/8 (62.5) | 14/25 (56) |
| Al-Harethee et al. (15) | NA | NA | NA | NA | NA | NA |
| Scaperrotta et al. (16) | No residual disease at surgical specimen | NA | NA | 16/32 (50) | 1/3 (33.3)d 2/4 (50)h |
19/39 (48.7) |
| Graham (17) | NA | NA | NA | NA | NA | NA |
| Milos et al. (20) | BLES produced a HRL or malignant lesion and the surgical specimen did not contain any remnants of the initial malignant or high-risk lesion | NA | 8/14 (57.1)i | 3/10 (30) | 4/10 (40) | 15/34 (44.1) |
| Sklair-Levy et al. (21) | NA | NA | NA | NA | NA | NA |
| Papapanagiotou et al. (22) | No residual disease at surgical specimen | NA | NA | 4/5 (80) | 21/45 (46.7) | 25/50 (50) |
| Niinikoski et al. (23) | Complete excision was based on histological margin status of the BLES sample | 19/43 (44.2)j | 6/10 (60)i | 2/3 (66.7) | 0/2 (0) | 27/58 (46.6) |
Values as presented in the articles; ADH atypical ductal hyperplasia; BLES breast lesion excision system; DICS ductal carcinoma in situ; HRL high-risk lesions; IDC invasive ductal carcinoma; n number of (benign/ADH/DCIS or IDC) complete excisions; N total number of initially benign/ADH/DCIS or IDC; NA not available;
aLow-grade DCIS
bIDC and other malignant lesions
cLesions with cell atypia
dIDC complete excision rate
eInvasive lobular carcinoma (ILC) complete excision rate
fBased on post-biopsy mammographic follow-up and specimen radiography
gADH, atypical lobular hyperplasia (ALH) and lobular carcinoma in situ (LCIS)
hDCIS with micro-invasion complete excision rate
iHigh-risk lesion complete excision rate
jBenign intraductal papilloma