Fig. 3.

Mutational map and enriched pathways in diagnosis/relapse pairs of NPM1^mut loss and persistent pts. a Mutational profile of 10 NPM1^mut loss and 10 NPM1^mut persistent pts found by WES. Colors indicate the varying occurrence of mutations during disease progression, including mutations which persist during remission (preleukemic/germline mutations; [green]), mutations which are solely present in the diagnosis sample (blue), relapse specific mutations (red) and mutations which are shared between the diagnosis and relapse sample (black). b Enriched pathways in diagnosis and relapse samples from NPM1^mut loss and NPM1^mut persistent pts based on mutated genes