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. 2019 Apr 26;7:88. doi: 10.3389/fbioe.2019.00088

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Copyright © 2019 Pei and Wei.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Two classes of USF contrast agents: (A) ICG-encapsulated PNIPAM NPs (Pei et al., 2014). Thermo-sensitive polymer: PNIPAM; environment-sensitive dye: ICG. (B) ADP-CA-encapsulated Pluronic micelle (Cheng et al., 2016). Thermo-sensitive polymer: Pluronic polymer; environment-sensitive dye: ADP-CA. Chemical structures of ICG (C) and ADP-CA (D). LCST: lower critical solution temperature. Insert (C) Transmission electron microscopy (TEM) image of (A), scale bar: 1 μm; Insert (D) TEM image of (B), scale bar: 100 nm. Reproduced with permission. Copyrights 2014©Springer Nature and 2016©PLOS.