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. 2019 Apr 26;7:88. doi: 10.3389/fbioe.2019.00088

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Copyright © 2019 Pei and Wei.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The USF image of the tube embedded into the porcine muscle tissue (Pei et al., 2014). ICG-encapsulated PNIPAM NPs were used as the contrast agents. The two dashed vertical lines represent the inner boundaries between the tube and USF contrast agents. (b) The diffraction-limited ultrasound image (C-mode) of the same tube in the tissue, obtained by raster scanning the same HIFU transducer on the x-y plane. (c) The profiles of the USF signal and the diffused fluorescence signal along the x axis at y = 0 (see the dashed horizontal line in (a). (d) The profiles of the USF, ultrasound, and temperature signals along the x axis at y = 0. Both the USF and ultrasound image were normalized and interpolated based on a bicubic method. Reproduced with permission. Copyright 2014^©Springer Nature.