Table 2.
Overview of components of USF contrast agents.
| linear polymer | polymer nanocomposite | micelle | |||
|---|---|---|---|---|---|
| Single fluorophore | DBD; St633; Sq660; St700; ADP-CA; ICG | PNIPA | PNIPA | Pluronic F-98; F-127 |
|
| Donor and acceptor (fluorophores) | DBD/ St660 | PNIPA | PNIPA | Surface | NR |
| DBD-ED /Sq660 | Core-to-surface | ||||
| Switchable threshold temperature tuner (co-polymers) | TBAm; AAm; AH; AAc | TBAm; AAm; AH; AAc | PEG-20K/ -30K/-40K |
||
| Targeting biomolecule anchor (functional groups) | AAc(carboxyl); AH(amine) | AAc(carboxyl); AH(amine) | NR | ||
| Others (surfactants) | n/a | SDS; F-127 (-carboxyl); F-98 |
PEG | ||
DBD-ED, [7-(2-Aminoethylamino)-N,Ndimethyl-4-benzofurazansulfonamide; ICG, indocyanine green; ADP-CA, chemical structure see Figure 5D; PNIPAM, poly(N-isopropylacrylamide); TBAm, N-tert-butylacrylamide; AAm, acrylamide; AAc, acrylic acid; AH, allylamine; SDS, sodium dodecyl sulfate; PEG, Polyethylene glycol; NR, not reported yet.