Table 3.
Univariable and multivariable linear regression analyses of albumin-adjusted plasma R-SH in CD with clinical and biochemical parameters.
| Plasma R-SH/gram of albumin | Univariable analysis |
Multivariable analysis |
||
|---|---|---|---|---|
| Variables | B coefficient# | P-value | B coefficient# | P-value |
| Age | –0.091 | 0.52 | ||
| Female | –0.044 | 0.76 | ||
| Current smoker | –0.099 | 0.49 | ||
| BMI | –0.345 | 0.01† | –0.337 | 0.02† |
| Prior surgery | 0.072 | 0.62 | ||
| HBI∗ | –0.087 | 0.58 | ||
| Treatment | ||||
| Thiopurines | 0.248 | 0.08 | ||
| Mesalamine | –0.194 | 0.17 | ||
| TNF-antagonists | 0.060 | 0.68 | ||
| Laboratory measurements | ||||
| Hemoglobin | –0.065 | 0.65 | ||
| CRP∗ | –0.300 | 0.03† | ||
| ESR∗ | –0.173 | 0.22 | ||
| WBC∗ | 0.061 | 0.67 | ||
| Platelets∗ | –0.134 | 0.35 | ||
| Albumin | –0.003 | 0.99 | ||
| AST | 0.105 | 0.46 | ||
| ALT∗ | –0.146 | 0.31 | ||
| eGFR | 0.056 | 0.70 | ||
| Creatinine | 0.015 | 0.92 | ||
| Fecal calprotectin∗ | 0.241 | 0.10 | ||
∗Skewed data have been logarithmically transformed before entry into analyses. #Standardized beta (β) coefficient. †P-values < 0.05 were considered statistically significant. Significances are indicated in bold. R-SH, free thiols; BMI, body mass index; HBI, Harvey Bradshaw Index; TNF, tumor necrosis factor; CRP, C-reactive protein; ESR, erythrocyte sedimentation rate; WBC, white blood cell count; AST, aspartate transaminase; ALT, alanine transaminase; eGFR, estimated glomerular filtration rate.