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. 2019 Apr 26;6:51. doi: 10.3389/fcvm.2019.00051

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Copyright © 2019 Potere, Del Buono, Mauro, Abbate and Toldo.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Overview of the biological properties of LRP1. (A) as a scavenger receptor, LRP1 binds and internalizes a wide range of ligands for degradation in lysosomes or recycling. (B) as a regulatory receptor, LRP1 modulates gene transcription through its intracellular domain (LRP-ICD) generated by intramembrane proteolysis and releases its extracellular ectodomain (soluble LRP [sLRP1]) in the circulation, where it exerts numerous biological functions. Alternatively, LRP1-ICD has the ability to recruit various adaptor proteins to transduce multiple intracellular signals. (C) as a scaffold receptor, LRP1 modulates the activity of other membrane proteins including integrins, tyrosine kinase (Trk) receptors and N-methyl-D-aspartate (NMDA) receptors.