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. 2019 Apr 26;6:51. doi: 10.3389/fcvm.2019.00051

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Copyright © 2019 Potere, Del Buono, Mauro, Abbate and Toldo.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Proposed model of LRP1 involvement in the reparative phase following AMI. (A) LRP1-mediated signaling promotes fibroblast survival, proliferation and differentiation in myofibroblast. LRP1 appears to potentiate transforming growth factor β (TGF-β) and connective tissue growth factor (CTGF) signaling, thus facilitating extracellular matrix (ECM) deposition and scar formation. (B) LRP1 plays a major role in tissue remodeling as it serves as a functional receptor for ECM proteinases and their own inhibitors.